Barbra Streisand explains 'Ozempic' comment on Melissa McCarthy's

Barbra Streisand is speaking out about a since-deleted Instagram comment she reportedly shared on one of Melissa McCarthy's posts, which drew backlash earlier this week.

"OMG - I went on Instagram to see the photographs we'd posted of the gorgeous blossoms I'd received for my birthday! Below them was a photo of my friend Melissa McCarthy who I sang with on my Encore album. She looked amazing!" Steisand wrote on X, formerly Twitter, on Tuesday. "I just wanted to pay her a compliment. I forgot the world is reading!"

The EGOT winner's explanation comes after the @commentsbycelebs Instagram account captured a screenshot of a response she purportedly wrote under McCarthy's latest post, which read, "Give him my regards did you take Ozempic?"

In McCarthy's post, she shared photos of herself and director Adam Shankman attending a Los Angeles gala. The "Bridesmaids" actress donned a mint green pleated dress with a coordinating bolero and high-heeled heels.

TMZ reported on Tuesday that a photographer accosted the "Gilmore Girls" actress about Streisand's remark. The outlet said McCarthy responded, "I think Barbra is a treasure and I love her."

Barbra Streisand addresses Melissa McCarthy Ozempic comment

The two previously sang together on Streisand's 2016 album, "Encore: Movie Partners Sing Broadway," rendering a duet on "Anything You Can Do" from "Annie Get Your Gun."

"She’s brilliant, attractive, intelligent, and so talented. Just like we chant at the conclusion of the tune — I’m her devotee!!" Streisand said of McCarthy shortly after the record released. In a making-of video, she dubbed McCarthy "the greatest woman comedy star."

Over the past year, weight reduction drugs, such as Ozempic and Wegovy, have become a part of our cultural lexicon, as more and more A-listers have quietly begun to share their experiences − both positive and negative − with these medications.

They got conceived with 'Ozempic babies'and quit the drug cold turkey. Then came the adverse effects

Ozempic is the brand name of semaglutide, just one of many in a pharmacological class known as incretins.

"Semaglutide (Ozempic or Wegovy) sends signals to the appetite center in your brain to reduce hunger and increase fullness," Dr. Deborah Horn, an associate professor in the Department of Surgery at McGovern Medical School at UTHealth Houston.

Barbra Streisand Asked Melissa McCarthy If She Used Ozempic

Horn explained, "This helps you feel satisfied with smaller portions and decreases the need for snacking … Wegovy diminishes what we call 'food distraction' so that we aren't thinking about food as much or using food to try and solve other problems."

In June 2021, the Food and Drug Administration approved the semaglutide – under the brand name Wegovy – as a treatment for chronic obesity. Since then, interest in the drug, which requires weekly injections, has skyrocketed. 

McCarthy, 53, has not responded to either of Streisand's posts.

Ozempic - a treatment originally designed for people with diabetes - works by suppressing the appetite and lengthens the amount of time food remains in the stomach, leading to weight loss - at least for as long as you carry on taking it.

It has been prohibited as a treatment for obesity in the UK due to high demand for the substance causing a global shortage.

Numerous Hollywood personalities are rumoured to have used Ozempic to reduce weight - but just a smattering of celebrities have acknowledged it publicly.